From salmon sperm facials to serums, PDRN skincare is beauty’s new fixation
From Cleopatra milk baths to the infused golden creams of golden mucin, the quest for eternal youth never lacked any imagination. In 2025, the gaze is much less romantic: salmon sperm. We have moved our research from the Elixir of the day to extract the DNA fragments from the fish, helped by the big titles led by celebrities, the facials of the salmon sperm would have been favored by Jennifer Aniston, Kim and Khloe Kardashian. The molecule is now leaving clinics and is presented in jars and droplets for daily routines, inaugurating a new wave of pdrn skin care. You may have already paraded it: stylish pink packaging for social networks or steel metal bottles that signal their clinical pedigree.
The molecule behind the buzz has a name as long as its chain: polydoxyribonucleotide or PDRN. It belongs to a wider family called polynucleotides, which includes DNA and RNA chains of variable lengths. Within this family, the PDRN refers to shorter DNA fragments. “In beauty treatments, they are most often taken from the DNA of salmon,” said dermatologist, Dr Manjot Marwah, director of LHR clinics and founder of Enagenbio. “The idea is that these parts can” speak “to our skin cells, helping them to renew, repair and appear younger.”
How it works is relatively simple. “Salmon DNA is very similar to human DNA. It does not trigger allergies. And he has powerful healing effects on the skin, ”explains Dr. Niketa Sonavane, dermatologist, founder of Aesthetics Aesthetics. Sonanave adds that when injected, these fragments stimulate repair, stimulates hydration, facilitate inflammation and gradually give the skin a more fluid and brighter finish. Dr. Marwah notes that he not only revives collagen and elastin, but also supports damaged skin healing.
In dermatology clinics, the PDRN has acquired a reputation for skin booster for problems ranging from pigmentation and sun damage to fine lines and acne scars. Dr. Sonavane saw that it works particularly well for the skin that is thin, dull or pancake, and often recommends it to the brides with an approach to the skin of the skin of their beauty look of the wedding day.
In its most powerful form, the PDRN is generally delivered through injectables. “This is the most active part of polynucleotide treatment,” explains Dr. Sonavane, “helping to improve blood supply and reduce oxidative stress”. Dr. Marwah has seen him go in topical PDRN skin care products, although absorption remains less deep compared to dermans and injectable into a clinic.
